The reactivity of our skin

Repeatedly, it has been demonstrated that cannabis-based preparations alleviate the symptoms of chronic skin diseases, such as eczema and psoriasis, and it seems that the endocannabinoid system plays an important role in the regulation of different fundamental processes involved. in inflammation. It is even possible that an imbalance of the endocannabinoid system (SE) is an important underlying cause.

What causes chronic skin diseases?

Chronic skin diseases, such as psoriasis or eczema (officially known as atopic dermatitis) can occur due to genetic, environmental or lifestyle-related influences, or a combination of all three. Psoriasis can also affect people who take certain prescription medications (including beta blockers, NSAIDs, and lithium), or those whose immune systems are severely weakened, such as HIV sufferers. The prevalence of psoriasis varies greatly between countries and is estimated at around 2-4% in Western countries. Have a look at hemp oil for psoriasis before and after.

The mechanism behind psoriasis affects the immune system. Research has recently discovered that the endocannabinoid system adheres to some of the messenger molecules of our immune system, thereby regulating a series of primary physiological functions. The main function of the endocannabinoid system seems to be to contribute to the balance of the cells, their proliferation, differentiation, tolerance and death. This is also true with regard to skin cells and dermatological problems.

The communication channels through which endogenous, plant or synthetic cannabinoids affect our immune system are beginning to be understood. These biochemical mechanisms influence four different actions, which are cellular apoptosis, the inhibition of cell proliferation, the suppression of cytokine production and the reduction of white blood cells or leukocytes. Cytokines are the main chemical signals of inflammation, secreted by immune cells in emergencies, and all these actions are part of the usual defensive strategy (in constant evolution) that our body applies at all times. This mechanism, verified in the laboratory, confirms that the activity of the endocannabinoid system could prevent, or at least mitigate,

Eliminating inflammation

Inflammation system cannabinoid psoriasis pain tissue breakage with psoriasis, the inflammatory state of the dermis causes premature maturation of the skin cells, causing pain and damage to the skin tissues. Scientific research has shown that hemp is a potent anti-inflammatory. If we focus on the non-psychotropic cannabinoid CBD, a review of several studies in 2010 suggested that substances that act on the CB2 receptors of the endocannabinoid system may constitute a treatment for inflammatory and autoimmune disorders. This discovery confirms the potential of CBD against psoriasis since it adheres to the CB2 receptor to exert its biochemical action on the signalling network of our immune system.

One of the clearest scientific evidence about the action of CBD on skin inflammation is entitled “Cannabidiol produces sebaceous and anti-inflammatory effects in human sebocytes.” This study shows that CBD develops a strong anti-acne action, by slowing down abnormal lipid production under the skin, suppressing cell proliferation and preventing seborrheic agents from raising cytokine levels and thus causing inflammation.

Balance of the cannabinoid system between layers of the skin

The action of cannabinoids goes far beyond fighting inflammations. Recent studies that discovered the functions of the endocannabinoid system in the skin, also showed that the imbalance of the endocannabinoids can facilitate the development of skin diseases, mild and severe. These findings open up new possibilities for hemp-based treatments, as mentioned in a study entitled “The endocannabinoid system of the skin in health and disease: new perspectives and therapeutic opportunities”.

If we continue to advance in the study of endocannabinoids, another report entitled “Epigenetic control of skin differentiation genes with phytocannabinoids” confirms that the endocannabinoid system plays a role in epidermal physiology. Anandamide is a cannabinoid produced by our body that regulates the expression of cutaneous differentiation genes, while cannabidiol (CBD) and cannabigerol (CBG) are phytocannabinoids that can control both cell proliferation and differentiation. This was confirmed in a study carried out in 2007 and published in the Journal of Dermatological Science. The scientists discovered that cannabinoids help prevent the accumulation of dead epidermal cells by inhibiting the proliferation of living cells. This effect supports the idea that marijuana extracts could be effective compounds for the treatment of skin diseases.

The advantages of cbd skin extracts

Cannabinoids have been shown to act as immunosuppressive and anti-inflammatory agents in skin diseases, as well as in many other pathologies of the immune system, such as multiple sclerosis, diabetes, rheumatoid arthritis and allergic asthma. Both CBD and THC buffer the body’s immune response, which is positive in conditions related to an overactive immune system. Since there are cannabinoid receptors in the cells along our skin, it is possible to treat dermatological problems with systemic and topical remedies. We must remember that the real therapeutic potential of marijuana is far from being exploited and, to this day, nobody is able to transfer the results of laboratories and the experiences of patients to a standardized clinical practice.

That said, the total absence of adverse effects makes CBD a perfect cannabinoid phytotherapeutic compound. The oil CBD has a number of inflammatory and antiproliferative properties that can combat the symptoms of psoriasis. Other hemp topics that can alleviate the signs of psoriasis are balms, creams or ointments that contain CBD, THC or other combinations of cannabinoids. Although topical or oral hemp remedies have virtually no toxicity factors, smoking marijuana could actually aggravate conditions such as psoriasis. The best choice to inhale hemp would be a vaporizer.

In most cases, the balms and oils of CBD soothe the damaged skin, although the results of the use of this herb depend to a large extent on the quality of the extract, as well as on the particular condition of the patient. Some individuals have seen their psoriasis disappear, others appreciate less inflammation and itching. In many cases, the hemp-based extract did not seem to work because its concentration of CBD was too low. This variable should be taken into account when testing homemade marijuana extracts to treat skin problems. Here we leave a great recipe to prepare potent lotions with hemp.